In the early 60s, Francis Crick (yes, that Nobel laureate) and colleagues demonstrated that the genetic code consisted of 3-letter 'words'. En route, they deduced it contains non-words ('stop' codons), and that many code words must be 'synonyms' calling for the same amino acid. These central insights about biology were achieved with nothing more than a couple varieties of E. coli (probably accessible from your local sewer) and a bacteriophage (bacterial virus). By the end of the unit, you'll have an active understanding of how they did it.
click the link to proceed to the simulation.
(Answer 'yes' if asked 'close window?')

Using the embedded help system

Bruce's favorite advice on problem solving (see blog posts on problem-solving strategies I and II. NOT required reading, but you may find it helpful)

The following are tutorials that will probably prove useful. They are accessible from inside the scenario from the 'Flash Tutorials' link in the Protocols menu. Note that the 'leave tutorial' button doesn't work if you access them here; use your browser's back button instead

rIIb system tutorial

translation and frameshifting tutorial

Genetics textbook pages (legal) on translation and reading frame

recombination tutorial

You work will be turned in as electronic entries through the D2L web-site of the course.
An example of a truly stellar graphical representation, made with ye olde LucidChart, can be found at the end of this link (check with your instructor regarding whether this is a relevant format for you).

Stop codons are starting to rear their ugly heads as stones in the road (ah, the beauty of a mixed metaphor), Follow THIS LINK to read some words that might provide some guidance...

To get the Shockwave plug-in that is required to run the simulations, click the icon below. You'll need to follow a series of installation instructions; just do as your told and click 'yes' whenever it asks your permission to do anything. You'll only need to do this once. You may already have it installed; if you try the simulation, it will either run OK or take you through the download process. Safari/Internet explorer browsers preferred; if you run into difficulties with Internet Explorer, you might want to try uninstalling the Shockwave plug-in first.