3D structure views from lab

Which sidechain types are internal?

Which sidechain types are external?

Surface helix: which residues 'point' which way?

A look at heme

Who would bind heme?

myoglobin vs. hemoglobin

What moves when oxygen binds?

What amino acids pair when oxygen is bound or released?

Part II: Bohr, Babies, Sickle

DPG binding

The Bohr effect histidine: high pH vs. low pH

Transcription, translation of sickle cell

Glu => Val location

Pocket for the valine

Chain of Glu=>Val hemoglobins